Hi @natters13 
Welcome to the forum!
Not permanently (thank goodness!). But yes, when I use a pussy pump the difference is extreme and generally lasts a good few hours. With the more powerful pumps it takes a while to build up to where your lower regions can take the pressure they exert. Probably though with pauses during pumping she will get to where she fills whatever pump cup you are using and left for a little while (NOT TOO LONG, you do not want to risk damage!) the effects will last at least an hour.
This is my review of the Doc Johnson Bloom which hopefully contains some useful info for you 